Chenyu Wen har fått ett doktorandstipendium från Wallenbergstiftelserna.

2020-04-09

Chenyu Wen has received a generous postdoctoral scholarship from The Knut and Alice Wallenberg Foundation. The host will be Prof. Martin Z. Bazant at the Department of Chemical Engineering, Massachusetts Institute of Technology (MIT). The project will last for two years and hopefully be launched before the end of 2020. 

Chenyu Wen has received a generous postdoctoral scholarship from The Knut and Alice Wallenberg Foundation. The host will be Prof. Martin Z. Bazant at the Department of Chemical Engineering, Massachusetts Institute of Technology (MIT). The project will last for two years and hopefully be launched before the end of 2020. The title of this project is Study of Ion/Molecule Transport in Nanoscale Channels for Protein Nanopore Profiling. Owing to its single-molecule resolution and sensitivity, nanopore technology has been explored for a wide range of applications in biomedicine. Attempts to transfer its success in DNA sequencing to protein profiling have been reported, since the knowledge of protein structure and function is important for biological and medical research and practice. Methods available today to determine protein structure are expensive and/or labor intensive, making nanopore technology a particularly attractive candidate for protein profiling. This project will allow Chenyu to establish a theoretical framework for nanopore protein recognition by being a postdoctoral fellow at MIT and by intimately collaborating with the Division of Solid-State Electronics, Department of Electrical Engineering, Uppsala University. Specifically, a set of models will be established for ion/water transport in nanoscale channels. Supported by modeling and simulation, the signal analysis methodology to decipher the signal waveform will be developed and validated via determination of the structure of a few characteristic proteins. This methodology will be utilized for nanopore design and validation by focusing on the correlation between related factors of nanopore and protein and the signal waveform.​​

Structure of the project showing the aims and tasks. Work package 1 (WP1): studying the mechanism of transport process where the classical theories fail, with a special focus on electrokinetics and hydrodynamics; work package 2 (WP2): addressing the complex interaction between the nanopore-translocating proteins and the dynamic electric field and electroosmotic flow as well as by deciphering the waveform of nanopore ionic currents upon protein passage; Work package 3 (WP3): focusing on the influence of nanopore geometry and dimension, nanopore surface charge and charge distribution, and protein structure on the waveform of nanopore ionic currents.
Senast uppdaterad: 2021-04-26